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KMID : 0359919940130030606
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Korean Journal of Nephrology
1994 Volume.13 No. 3 p.606 ~ p.613
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Study on T-Lymphocyte Subsets in Hemorrhagic Fever with Renal Syndrome by Flow Cytometer
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Abstract
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Korean hemorrhagic fever, known as hemorrhagic fever with renal syndrome, is an acute, is an acute infectious disease caused by Hantaan virus. Pathogenesis of Korean hemorrhagic fever (KHF) is not clearly delineated to date. Recently the
immunogic
mechanisms of KHF have been investigated by many authors.
To clearify the role of immunemechanism in the pathogenesis of KHF, lymphocyte subsets were measured by Flow cytomerty in the periperal blood with 8 patients during the acute phase of KHF and 10 months later. During the acute phase of KHF the
percentage
of CD4 decreased and CD 8 and activated T cell increased significantly compared to 10 months later of acute phase of KHF.
These results suggest that variation of lymphoctye subsets distribution occurred in acute phase of KHF and it may be related to pathogenesis of KHF.
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KEYWORD
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